When you get a chance take a measurement of your truck ( top of bed rail to the ground), post it so we can give you the correct answer to your question.Thinking about getting a Road Warrior 385rw and I am worried that my truck might sit to high. I have an 2002 F250 4x4 with a 2" lift and 285r16 tires. Is there anyone with the same set?
With all that has been said above, I'd be cautious of the bed side rails. If you try to lower the 5th wheel hitch to level it up, you may encounter damage to the side rails during sharp turns. And it is especially worse if you are turning with dips in the road. Been there, done that. Costly damage.
After thought: Oh, I should add that I didn't have a lift either.
That truck your driving sits pretty high already. I looked at a friends truck who has a 2009 or 2010 Dodge 3500 DRW 4x4 mega cab and his truck sits about the same as mine. So I think I shoud be fine. I'll keep an eye out for the large dips.
Wow...that is HIGH, my 08 250 4x4 w/ 20" wheels sits rather high @ 56". I had to raise my Sundance 3" to be almost level. (making both truck and 5er level).It measures 59" from the ground to the top of bed rail.
One other possible concern you may want to consider that hasn't been addressed. I did a quick check on your truck year tow rating and it may be too light for the RW. I recommend you read the article, Before You Buy - It's not rocket science and check the Ford towing guide on the site as well.