Hi lordmetroid,
Welcome to the Heartland Owners Forum.
The main active parts are the electric heating unit, the thermistor, and although the cooling unit is passive, it has to maintain its integrity.
I don't know that a lot of us have 10-15 years experience with a single refrigerator to be able to answer definitively. That said, I think the chemicals used in the cooling unit are corrosive, so as the unit ages, it's possible you could develop a leak in the cooling unit before you get to 15 years. Residential refrigerators can also develop leaks in the cooling system in the same time frame (probably from vibration), so I'm not sure it's any worse.
Seals will likely need replacement, just like on an aging residential refrigerator.
If you do have a failure, it's not that hard to get a Dometic refrigerator repaired or replaced, although it can be expensive compared to a residential refrigerator.