Hi linnertz,
Welcome to the Heartland Owners Forum.
When tanks are full and you open the gate valves, sometimes the water coming through the drain pipes doesn't go down the sewer fast enough, and it backs up all the way to the tanks. If you had a crack in the top of one of the drain lines, it might do what you're describing.
Have you had any problems after winterizing? If there was water in the sewer lines over the winter, maybe one of the pipes cracked.