Michael;
That's a tough question to answer since you didn;t give us any information. I like to travel secondary roads, rather than interstates. There are several programs available to help in route selection and most give the option of fastest route or shortest route or you can do a custom route. Map Quest, Good Sam's, Flying J, are three. I personally use two, Microsoft Streets and Trips and Magellan. There are others and if you let us know how many miles or hours you plan to travel each day and the roads that you prefer to travel, you will probably get lots of answers.
John