Hi bikerchick,
We have the same truck. The 7.3 engine is a great engine. It can handle a a lot. We do have the short bed, SRW, not sure what you have. We have added air bags, trans cooler and The Edge Evolution (Performance Programmer). We typically get about 18-19 mpg when not towing. But towing the BH 3670RL, we get about 11-12 mpg on the flat lands and going uphill it goes down from there. Actually, last month we were coming out of Death Valley through some very steep mountains, with a 10% grade (we WILL NOT do that again, brakes got hot, it was scary) and it was showing down to 3.7 mpg. Yikes! The Edge saved our butt, because we could see it was starting to heat up and we pulled over to cool the engine and the brakes. We found that dropping down one gear (and going slower, 30 mph) really helped keeping the engine cooler. I would definitely suggest getting a performance monitor if you are going to pull one of the heavier trailers. So glad we had it. Saved us for doing any damage.
Like so many here have stated, there are so many variables. Which rv model you choose, how heavy you pack it, whether you are going up or down a hill, or not. That being said, the 7.3 will pull them no problem. Just watch the hills. Our mechanic says it's one of the better engines Ford made. Stick with it.