Something to keep in mind is that weight is not evenly distributed. One tire may be carrying hundreds of pounds more than the next. If your sidewall calls for 80 PSI and you inflate to 70 PSI because your trailer is lightly loaded, you might be under-inflated on one or more tires due to uneven loading.
The simplest and safest thing is to set the tire pressure to the Cold Max as shown on the sidewall, measured when tires are cool, ideally at 70 (F) outside, and not in direct sun.
If you've upgraded tires to a higher load capacity, like going from GY 614 (3750 lbs @ 110 PSI) to GY 114 (4805 lbs @ 125 PSI), you probably don't want to inflate the 114s all the way to 125 PSI. You'd look up Goodyear's load table and perhaps set the pressure to a lower number that provides higher load capacity than your old 614s, but not all the way to 4805 lbs.