Good evening
I am not sure what route you are going to take through San Francisco. But I will would give a couple words of advice:
1. Google events in San Francisco: see if any events are going on such as Bay 2 breakers or something else along your planned route in the city
2. I would do it early in the morning say around 5 or 6 am with less traffic
3. Stay in the far right hand lane of the Golden Gate Bridge. It is the widest and the lanes on the bridge are pretty narrow.
Have a good night
Eric