Plys in terms of tires are a left over comparison from the days they manufactured tires with cotton belts. In today’s world you go by the load range regardless what it states on the sidewall for plys. Load range “G” tires are going to be the equivalent of a 14 ply tire.
Let me give you you a perspective, what is stronger a 30 lb fishing line or 3 10 lb fishing lines. That is how I explained to people why one tire stated a 2 ply sidewall while another tire same size and Load range may have said 3 or 4 ply sidewall. The advantage of the increased sidewall plys would be a little more resistant to sidewall damage such as scuffing or damage by snagging something. The downside could be ride comfort, less overall tire wear mileage. The more plys in a tire typically the more internal heat generation because of the plys rubbing against each other. Number one enemy of a tire is heat.
Bottom line is don’t get hung up on the construction of the tire (in most applications) but be more concerned with the LR. For trailers and most RV applications almost every tire meant for highway use, less aggressive tread design or all season tread design will work great as long as you pay attention to having the correct load range for the application (and as a side note the correct wheel and valve stem).