We have traveled in up to 110-120 degree temps. in the desert for years.
Carry plenty of drinking water.
I try not to let fuel go below half, if I'm in remote areas. You don't want to get stuck running out of fuel, especially in brutal heat.
Also, remember your equipment has to work a little harder in the heat. I try to go a little easier on mine.
If you don't have an onboard generator, you might consider getting a portable that will run your air.
If you get stuck or have to park without hookups, you will at least have A/C.
We run our second A/C occasionally, when temps go over 100+. If you plan on traveling in heat a lot, a second A/C is nice. JMHO. Trace