If you are talking about your trailer, they should be set according to the load on them plus 5 psi or maximum. If the sidewall says max 80psi put 80psi in them until you know the weight fully loaded and then get the load pressure chart for your tires. On my fifth wheel the Goodyear G614's, a 110 max psi tire, needs 90psi and do to the mountain/sea level/desert traveling we do, I set them at 100psi. For an entire trip I never need to adjust the air pressure unless one tire differs more then 2psi in the morning.
For your truck, set it to the manufactures specified psi. Check my trucks manufactures recommended pressure against the load pressure chart I down loaded form the manufactures web page. The rear PSI was specified for the maximum load the dully could carry. I could lower the psi based on the manufactures load pressure chart, but what a pain to refill each time I what to used it to pull the fifth wheel.
So unless your trailer has been weighed fully loaded and the load has been weighed on each tire individually, you really need to keep them at maximum pressure or the Heartland recommended pressure for safety. I think that there is a sticker on mine that says 80psi. That was for the Blowmax tires that were 80psi max that came with the fifth wheel.