It is a great trip. We just moved back to Missouri from living in Alaska for 8 years. Many times the frost heaves will be marked by little orange flags on the side of the road. Just be sure and be careful over those and slow down on the gravel stretches.
Also, we have found the people along the way to be really nice.
Anchorage is the biggest city and a good place to spend a day or maybe two, but don't plan to stay there long (this is where I lived). It has a nice downtown Saturday or Sunday market and lots of neat shoppes and restuarants.
Our favorite get-a-way was Seward. You can take whale watching cruises out of there and the town is really nice and peaceful. If you have any questions that we might be able to answer, feel free to send a PM.