While I'm not an expert on A/C, I've installed adjustable vents on ours. Our living room unit has ducts running into the bedroom and bathroom. During the day I often close those partially or fully. I've also closed 2 vents over the kitchen. The idea was to direct more cool air to the sitting area. And our bedroom A/C is non-ducted. When it's running there's no need for cool air running from the living room unit. At night, I turn off the bedroom A/C (too noisy to sleep under it) and open the vents.
Will it cause problems? I don't know. But I've been doing this for at least 4 or 5 years without a problem.