I found this information, in case anyone is intrested...
http://www.discounttire.com/dtcs/infoSeparationAnxiety.dos
Part of the document:
FAILURE ANALYSIS
Even properly rated tires can fail. The No. 1 cause is underinflation. This is particularly true of an ST tire, which relies on proper inflation to live up to its load rating. Without enough air pressure, an ST sidewall will not function as designed, and will eventually fail, usually in the form of a sidewall blowout. Tires lose approximately 1 psi per month as well as 1 psi for every 10-degree drop in temperature.
Overinflation is also hard on a tire, causing irregular wear and possibly a blowout. Yet, you can't always spot improper inflation with a visual inspection, so check your tires frequently with an accurate air-pressure gauge.
Long-term fatigue can also weaken a trailer tire. There are a number of factors that accelerate fatigue, but heat buildup from towing at high speeds is one of the main culprits, according to Fry.
"If you trailer nonstop from Phoenix, Arizona, to Las Vegas, in 100-degree temperatures at 65 mph, you use up much of the resources of that tire, and you don't realize it," said Fry.
Fry is not talking about wearing out the tread. It is the tire's construction that is breaking down. As heat builds up, the tire's structure starts to disintegrate and weaken. Over the course of several trips, this load-carrying capacity gradually decreases, according to Fry.
Incidentally, all ST tires have a maximum speed rating of 65 mph.
One key to extending tire life on a tandem- or tri-axle trailer is to ensure that the trailer is riding level, thus distributing the load equally among all the tires. If the trailer tongue sits too high, the rear tires may bear the brunt of the load: with the trailer tongue too low, the front tires may be unduly stressed.