Our old Class C motorhome, dual rear wheels. Had outer passenger dual fail one trip while towing tri-axle trailer with full-size pickup behind RV. Some nice folks stopped with a rolling floor jack and helped me change the tire (much better than the tools I had on hand and it was blazing hot out).
Our last Class A motorhome, had an inside driver dual fail, tread separated (loud) on the eway. We continued to an off ramp, went to a large parking area and call road service. I had it pretty much changed by the time they arrived and started to doubt the fees paid for such a service. Upside, that RV had full hydraulic leveling jacks so it was easy to lift the vehicle off the ground.
The next set of tires we put on there had multiple failures within a year, side wall would actually rupture in a true "blow out" fashion. Inside passenger dual failed and didn't notice, but while at the RV dealer with the rig, they did and helped me change it (failure had to have happened not far from there). Caught the next one (same set of tires) before the rupture, it had a huge "bubble" on the sidewall.
Needless to say, the remaining tires from that set were thrown away and a different brand was installed. Had passenger front with cord/ply separation (impact on highway pothole, I think) and while it didn't fail per se, it was literally a square tire when done, rig would waddle side to side as you rolled through the parking lot.
On my 2011 F150 (SRW, obviously) had the driver rear fail after hitting a chunk of steel debris on the eway while towing one of our enclosed trailers (7x16). Tire pressure monitor told me of the impending failure. We hit the next off ramp and went to the nearest fuel station. Found the cut, it went through the cords on the face of the tire. Put in a plug and aired it up and was good to go for home. Replaced that tire once we got home, the plug would hold while moving, but would leak down over night.
I've had inner and outer duals fail, fronts fail (but not in major fashion) and rears fail on SRW. There's a better chance you can "limp" somewhere with one failed dual but there's also the probability that the inner dual pressure will be neglected and fail sooner than it should.